Cyclic Hypervalent Iodine Reagents for Azidation: Safer Reagents and Photoredox-Catalyzed Ring Expansion
نویسندگان
چکیده
منابع مشابه
Cyclic Hypervalent Iodine Reagents for Atom-Transfer Reactions: Beyond Trifluoromethylation.
Hypervalent iodine compounds are privileged reagents in organic synthesis because of their exceptional reactivity. Among these compounds, cyclic derivatives stand apart because of their enhanced stability. They have been widely used as oxidants, but their potential for functional-group transfer has only begun to be investigated recently. The use of benziodoxol(on)es for trifluoromethylation (To...
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In the past decades azides have received increasing attention due to their exceptional reactivity and versatility in organic chemistry. Their use as non-basic precursors of amines or their easy conversion to nitrene intermediates for further C-N bond transformations made them key building blocks in chemistry, biology and material science. In spite of their hailed synthetic utility, their instal...
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This chapter describes recent developments in stereoselective synthesis using hypervalent iodine reagents.
متن کاملStereoselective synthesis of 5-7 membered cyclic ethers by deiodonative ring-enlargement using hypervalent iodine reagents.
Stereoselective synthesis of 5-7 membered cyclic ethers was achieved by deiodonative ring-enlargement of cyclic ethers having an iodoalkyl substituent. The reaction took place readily under mild conditions using hypervalent iodine compounds and an acetoxy or a trifluoroacetoxy group was introduced into the rings depending on the hypervalent iodine reagent employed. The use of hexafluoroisopropa...
متن کاملThioamination of Alkenes with Hypervalent Iodine Reagents
An efficient thioamination of alkenes mediated by iodine(III) reagents is described. The use of different sulfur nucleophiles allows the flexible synthesis of 1,2-aminothiols from alkenes. By employing chiral iodine(III) reagents, a stereoselective version of the thioamination protocol has also been developed.
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ژورنال
عنوان ژورنال: The Journal of Organic Chemistry
سال: 2018
ISSN: 0022-3263,1520-6904
DOI: 10.1021/acs.joc.8b02068